Ontology highlight
ABSTRACT:
SUBMITTER: Traore B
PROVIDER: S-EPMC2788035 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Vaccine 20090825 52
Antibodies play a key role in controlling blood stage malaria infections, and an effective blood stage malaria vaccine will likely require that it induce vaccine-specific memory B cells (MBCs). Our previous studies showed that the addition of the TLR9 agonist CpG to Plasmodium falciparum protein subunit vaccines greatly increased their efficacy in inducing MBCs in nonimmune U.S. volunteers. Here we show that in contrast the same CpG-containing malaria vaccine did not enhance the acquisition of M ...[more]