Ontology highlight
ABSTRACT:
SUBMITTER: Kazarian M
PROVIDER: S-EPMC2788043 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Kazarian Meleeneh M Calbo Joaquim J Proost Natalie N Carpenter Catherine L CL Berns Anton A Laird-Offringa Ite A IA
Journal of neuroimmunology 20090917 1-2
Most patients with paraneoplastic encephalomyelitis/sensory neuronopathy PEM/SN have small-cell lung cancer (SCLC) and develop antibodies against neuronal-specific Hu proteins, which are abnormally expressed in the tumor. Anti-Hu reactivity is present in ~16% of SCLC patients without PEM/SN. Here we test the hypothesis that engineered SCLC-prone mice may exhibit anti-Hu reactivity. We show that tumors from SCLC-prone mice misexpress Hu proteins, and 14% of mice harbor anti-Hu antibodies. Mice ap ...[more]