Ontology highlight
ABSTRACT:
SUBMITTER: Browne CD
PROVIDER: S-EPMC2788083 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Browne Cecille D CD Del Nagro Christopher J CJ Cato Matthew H MH Dengler Hart S HS Rickert Robert C RC
Immunity 20091105 5
Anergy is a critical physiologic mechanism to sensor self-reactive B cells. However, a biochemical understanding of how anergy is achieved and maintained is lacking. Herein, we investigated the role of the phosphoinositide 3-kinase (PI3K) lipid product PI(3,4,5)P(3) in B cell anergy. We found reduced generation of PI(3,4,5)P(3) in anergic B cells, which was attributable to reduced phosphorylation of the PI3K membrane adaptor CD19, as well as increased expression of the inositol phosphatase PTEN. ...[more]