Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.
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ABSTRACT:
SUBMITTER: Hayashi T
PROVIDER: S-EPMC2788208 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.
Hayashi Takashi T Thomas Gareth M GM Huganir Richard L RL
Neuron 20091001 2
Modification of NMDA receptor function and trafficking contributes to the regulation of synaptic transmission and is important for several forms of synaptic plasticity. Here, we report that NMDA receptor subunits NR2A and NR2B have two distinct clusters of palmitoylation sites in their C-terminal region. Palmitoylation within the first cluster on a membrane-proximal region increases tyrosine phosphorylation of tyrosine-based internalization motifs by Src family protein tyrosine kinases, leading ...[more]
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