KN-62 analogues as potent differentiating agents of HL-60 cells.
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ABSTRACT:
SUBMITTER: Schuler AD
PROVIDER: S-EPMC2788433 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
KN-62 analogues as potent differentiating agents of HL-60 cells.
Schuler Aaron D AD Si Jutong J Mueller LeMoyne L Simon Julian A JA Collins Steven J SJ
Leukemia research 20060911 5
KN-62, an inhibitor of the calmodulin-dependent protein kinases (CaMKs), enhances the terminal differentiation of retinoic acid sensitive human myeloid leukemia cell lines. In an effort to identify additional CaMK inhibitors that exhibit more potent activity in triggering leukemia cell differentiation, we synthesized 45 analogues of KN-62 and determined their ability to induce HL-60 cell differentiation. Sixteen of these novel analogues exhibited significant differentiation-inducing activity, an ...[more]
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