CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma.

ABSTRACT:

Background

Clear cell renal cell carcinoma (ccRCC) and chromophobe renal cell carcinoma (chRCC) can usually be distinguished by histologic characteristics. Occasionally, diagnosis proves challenging and diagnostic difficulty will likely increase as needle biopsies of renal lesions become more common.

Methods

To identify markers that aid in differentiating ccRCC from chRCC, we used gene expression profiles to identify candidate markers that correlate with histology. 39 antisera and antibodies, including 35 for transcripts identified from gene expression profiling, were evaluated. Promising markers were tested on a tissue microarray (TMA) containing 428 renal neoplasms. Strength of staining of each core on the TMA was formally scored and the distribution of staining across dif

SUBMITTER: Williams AA 

PROVIDER: S-EPMC2788570 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature