Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
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ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC2788761 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.
Zhang Qing Q Gu Jinming J Li Lianjie L Liu Jiayun J Luo Biao B Cheung Hiu-Wing HW Boehm Jesse S JS Ni Min M Geisen Christoph C Root David E DE Polyak Kornelia K Brown Myles M Richardson Andrea L AL Hahn William C WC Kaelin William G WG Bommi-Reddy Archana A
Cancer cell 20091101 5
2-Oxoglutarate-dependent dioxygenases, including the EglN prolyl hydroxylases that regulate HIF, can be inhibited with drug-like molecules. EglN2 is estrogen inducible in breast carcinoma cells and the lone Drosophila EglN interacts genetically with Cyclin D1. Although EglN2 is a nonessential gene, we found that EglN2 inactivation decreases Cyclin D1 levels and suppresses mammary gland proliferation in vivo. Regulation of Cyclin D1 is a specific attribute of EglN2 among the EglN proteins and is ...[more]
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