Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.
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ABSTRACT:
SUBMITTER: Niu H
PROVIDER: S-EPMC2788773 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.
Niu Hengyao H Wan Lihong L Busygina Valeria V Kwon YoungHo Y Allen Jasmina A JA Li Xue X Kunz Ryan C RC Kubota Kazuishi K Wang Beatrice B Sung Patrick P Shokat Kevan M KM Gygi Steven P SP Hollingsworth Nancy M NM
Molecular cell 20091101 3
A preference for homologs over sister chromatids in homologous recombination is a fundamental difference in meiotic versus mitotic cells. In budding yeast, the bias for interhomolog recombination in meiosis requires the Dmc1 recombinase and the meiosis-specific kinase Mek1, which suppresses engagement of sister chromatids by the mitotic recombinase Rad51. Here, a combination of proteomic, biochemical, and genetic approaches has identified an additional role for Mek1 in inhibiting the activity of ...[more]
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