Ontology highlight
ABSTRACT:
SUBMITTER: Yang FC
PROVIDER: S-EPMC2788814 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Yang Feng-Chun FC Ingram David A DA Chen Shi S Zhu Yuan Y Yuan Jin J Li Xiaohong X Yang Xianlin X Knowles Scott S Horn Whitney W Li Yan Y Zhang Shaobo S Yang Yanzhu Y Vakili Saeed T ST Yu Menggang M Burns Dennis D Robertson Kent K Hutchins Gary G Parada Luis F LF Clapp D Wade DW
Cell 20081001 3
Interactions between tumorigenic cells and their surrounding microenvironment are critical for tumor progression yet remain incompletely understood. Germline mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1 (NF1), a common genetic disorder characterized by complex tumors called neurofibromas. Genetic studies indicate that biallelic loss of Nf1 is required in the tumorigenic cell of origin in the embryonic Schwann cell lineage. However, in the physiologic state, Schwann c ...[more]