Ontology highlight
ABSTRACT:
SUBMITTER: Link W
PROVIDER: S-EPMC2788888 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Link Wolfgang W Oyarzabal Julen J Serelde Beatriz G BG Albarran Maria Isabel MI Rabal Obdulia O Cebriá Antonio A Alfonso Patricia P Fominaya Jesus J Renner Oliver O Peregrina Sandra S Soilán David D Ceballos Plácido A PA Hernández Ana-Isabel AI Lorenzo Milagros M Pevarello Paolo P Granda Teresa G TG Kurz Guido G Carnero Amancio A Bischoff James R JR
The Journal of biological chemistry 20090818 41
Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. A cell-based imaging assay that monitored the translocation of the Akt effector protein, Forkhead box O (FOXO), from the cytoplasm to the nucleus was employed to screen a collection of 33,992 small molecules. The positive compounds were used to screen kinases known to be involved in FOXO translocation. Pyrazolopyrimidine derivatives were found to be potent FOXO reloca ...[more]