Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto S
PROVIDER: S-EPMC2789807 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Yamamoto Shinichiro S Shimizu Shunichi S Kiyonaka Shigeki S Takahashi Nobuaki N Wajima Teruaki T Hara Yuji Y Negoro Takaharu T Hiroi Toshihito T Kiuchi Yuji Y Okada Takaharu T Kaneko Shuji S Lange Ingo I Fleig Andrea A Penner Reinhold R Nishi Miyuki M Takeshima Hiroshi H Mori Yasuo Y
Nature medicine 20080608 7
Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca(2+)-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H(2)O(2)) evokes Ca(2+) influx through TRPM2 to activate Ca(2+)-dependent tyrosine kinase Pyk2 and amplify Erk signaling via Ras GTPase. This elicits nuclear translocation of nuclear factor-kappaB ...[more]