Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
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ABSTRACT:
SUBMITTER: Kang JE
PROVIDER: S-EPMC2789838 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
Kang Jae-Eun JE Lim Miranda M MM Bateman Randall J RJ Lee James J JJ Smyth Liam P LP Cirrito John R JR Fujiki Nobuhiro N Nishino Seiji S Holtzman David M DM
Science (New York, N.Y.) 20090924 5955
Amyloid-beta (Abeta) accumulation in the brain extracellular space is a hallmark of Alzheimer's disease. The factors regulating this process are only partly understood. Abeta aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of Abeta. Using in vivo microdialysis in mice, we found that the amount of ISF Abeta correlated with wakefulness. The amount of ISF Abeta also significantly increased during acute sleep deprivation ...[more]
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