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Biomedical applications of chemically-modified silk fibroin.


ABSTRACT: Silk proteins belong to a class of unique, high molecular weight, block copolymer-like proteins that have found widespread use in biomaterials and regenerative medicine. The useful features of these proteins, including self-assembly, robust mechanical properties, biocompatibility and biodegradability can be enhanced through a variety of chemical modifications. These modifications provide chemical handles for the attachment of growth factors, cell binding domains and other polymers to silk, expanding the range of cell and tissue engineering applications attainable. This review focuses on the chemical reactions that have been used to modify the amino acids in silk proteins, and describes their utility in biomedical applications.

SUBMITTER: Murphy AR 

PROVIDER: S-EPMC2790051 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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Biomedical applications of chemically-modified silk fibroin.

Murphy Amanda R AR   Kaplan David L DL  

Journal of materials chemistry 20090601 36


Silk proteins belong to a class of unique, high molecular weight, block copolymer-like proteins that have found widespread use in biomaterials and regenerative medicine. The useful features of these proteins, including self-assembly, robust mechanical properties, biocompatibility and biodegradability can be enhanced through a variety of chemical modifications. These modifications provide chemical handles for the attachment of growth factors, cell binding domains and other polymers to silk, expan  ...[more]

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