Ontology highlight
ABSTRACT:
SUBMITTER: Costagli A
PROVIDER: S-EPMC2790411 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Costagli Arianna A Felice Barbara B Guffanti Alessandro A Wilson Stephen W SW Mione Marina M
Development genes and evolution 20060307 6
We have investigated the genomic organization, the occurrence of alternative splicing and the differential expression of the zebrafish disabled1 (dab1) gene. Dab1 is a key effector of the Reelin pathway, which regulates neuronal migration during brain development in vertebrates. The coding region of the zebrafish dab1 gene spans over 600 kb of genomic DNA and is composed of 15 exons. Alternative splicing in a region enriched for tyrosine residues generates at least three different isoforms. Thes ...[more]