Tissue-penetrating delivery of compounds and nanoparticles into tumors.
Ontology highlight
ABSTRACT:
SUBMITTER: Sugahara KN
PROVIDER: S-EPMC2791543 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Tissue-penetrating delivery of compounds and nanoparticles into tumors.
Sugahara Kazuki N KN Teesalu Tambet T Karmali Priya Prakash PP Kotamraju Venkata Ramana VR Agemy Lilach L Girard Olivier M OM Hanahan Douglas D Mattrey Robert F RF Ruoslahti Erkki E
Cancer cell 20091201 6
Poor penetration of drugs into tumors is a major obstacle in tumor treatment. We describe a strategy for peptide-mediated delivery of compounds deep into the tumor parenchyma that uses a tumor-homing peptide, iRGD (CRGDK/RGPD/EC). Intravenously injected compounds coupled to iRGD bound to tumor vessels and spread into the extravascular tumor parenchyma, whereas conventional RGD peptides only delivered the cargo to the blood vessels. iRGD homes to tumors through a three-step process: the RGD motif ...[more]
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