Ontology highlight
ABSTRACT:
SUBMITTER: Ryan SD
PROVIDER: S-EPMC2791600 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Ryan Scott D SD Whitehead Shawn N SN Swayne Leigh Anne LA Moffat Tia C TC Hou Weimin W Ethier Martin M Bourgeois André J G AJ Rashidian Juliet J Blanchard Alexandre P AP Fraser Paul E PE Park David S DS Figeys Daniel D Bennett Steffany A L SA
Proceedings of the National Academy of Sciences of the United States of America 20091119 49
Perturbation of lipid second messenger networks is associated with the impairment of synaptic function in Alzheimer disease. Underlying molecular mechanisms are unclear. Here, we used an unbiased lipidomic approach to profile alkylacylglycerophosphocholine second messengers in diseased tissue. We found that specific isoforms defined by a palmitic acid (16:0) at the sn-1 position, namely 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (C16:0 PAF) and 1-O-hexadecyl-sn-glycero-3-phosphocholine ( ...[more]