Ontology highlight
ABSTRACT:
SUBMITTER: A-Gonzalez N
PROVIDER: S-EPMC2791787 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Immunity 20090730 2
Effective clearance of apoptotic cells by macrophages is essential for immune homeostasis. The transcriptional pathways that allow macrophages to sense and respond to apoptotic cells are poorly defined. We found that liver X receptor (LXR) signaling was important for both apoptotic cell clearance and the maintenance of immune tolerance. Apoptotic cell engulfment activated LXR and thereby induced the expression of Mer, a receptor tyrosine kinase critical for phagocytosis. LXR-deficient macrophage ...[more]