Ontology highlight
ABSTRACT:
SUBMITTER: Simberg D
PROVIDER: S-EPMC2792080 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Simberg Dmitri D Park Ji-Ho JH Karmali Priya P PP Zhang Wan-Ming WM Merkulov Sergei S McCrae Keith K Bhatia Sangeeta N SN Sailor Michael M Ruoslahti Erkki E
Biomaterials 20090426 23-24
In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-binding blood proteins using novel two-dimensional differential mass spectrometry approach. The identified proteins showed specificity for surface domains of the nanoparticles: mannan-binding lectins bound to the dextran coating, histidine-rich glycoprotein and kininogen bound to the iron oxide part, and the complem ...[more]