Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC2792355 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
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Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2.
Zhang X X Beaulieu J-M JM Gainetdinov R R RR Caron M G MG
Cellular and molecular life sciences : CMLS 20060101 1
Many neuropsychiatric disorders are considered to be related to the dysregulation of brain serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. In this short review, we will ...[more]
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