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Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.

ABSTRACT: It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor.Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure (

SUBMITTER: Bhatnagar V 

PROVIDER: S-EPMC2792638 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial.

Bhatnagar Vibha V   O'Connor Daniel T DT   Schork Nicholas J NJ   Salem Rany M RM   Nievergelt Caroline M CM   Rana Brinda K BK   Smith Douglas W DW   Bakris George L GL   Middleton John P JP   Norris Keith C KC   Wright Jackson T JT   Cheek Deanna D   Hiremath Leena L   Contreras Gabriel G   Appel Lawrence J LJ   Lipkowitz Michael S MS  

Journal of hypertension 20071001 10

<h4>Objective</h4>It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor.<h4>Methods</h4>Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target me  ...[more]

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