Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC2793031 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Li Jincheng J Donath Stefan S Li Yanrui Y Qin Danian D Prabhakar Bellur S BS Li Peifeng P
PLoS genetics 20100108 1
miRNAs participate in the regulation of apoptosis. However, it remains largely unknown as to how miRNAs are integrated into the apoptotic program. Mitochondrial fission is involved in the initiation of apoptosis. It is not yet clear whether miRNAs are able to regulate mitochondrial fission. Here we report that miR-30 family members are able to regulate apoptosis by targeting the mitochondrial fission machinery. Our data show that miR-30 family members can inhibit mitochondrial fission and the co ...[more]