Ontology highlight
ABSTRACT:
SUBMITTER: Ruepp MD
PROVIDER: S-EPMC2793296 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Ruepp Marc-David MD Aringhieri Chiara C Vivarelli Silvia S Cardinale Stefano S Paro Simona S Schümperli Daniel D Barabino Silvia M L SM
Molecular biology of the cell 20091201 24
Export of mRNA from the nucleus is linked to proper processing and packaging into ribonucleoprotein complexes. Although several observations indicate a coupling between mRNA 3' end formation and export, it is not known how these two processes are mechanistically connected. Here, we show that a subunit of the mammalian pre-mRNA 3' end processing complex, CF I(m)68, stimulates mRNA export. CF I(m)68 shuttles between the nucleus and the cytoplasm in a transcription-dependent manner and interacts wi ...[more]