TMEM8 - a non-globin gene entrapped in the globin web.
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ABSTRACT:
SUBMITTER: Philonenko ES
PROVIDER: S-EPMC2794187 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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TMEM8 - a non-globin gene entrapped in the globin web.
Philonenko Elena S ES Klochkov Denis B DB Borunova Victoria V VV Gavrilov Alexey A AA Razin Sergey V SV Iarovaia Olga V OV
Nucleic acids research 20091201 22
For more than 30 years it was believed that globin gene domains included only genes encoding globin chains. Here we show that in chickens, the domain of alpha-globin genes also harbor the non-globin gene TMEM8. It was relocated to the vicinity of the alpha-globin cluster due to inversion of an approximately 170-kb genomic fragment. Although in humans TMEM8 is preferentially expressed in resting T-lymphocytes, in chickens it acquired an erythroid-specific expression profile and is upregulated upo ...[more]
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