Ontology highlight
ABSTRACT:
SUBMITTER: Calmon MF
PROVIDER: S-EPMC2794514 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Calmon Marilia F MF Rodrigues Rodrigo V RV Kaneto Carla M CM Moura Ricardo P RP Silva Sabrina D SD Mota Louise Danielle C LD Pinheiro Daniel G DG Torres Cesar C de Carvalho Alex F AF Cury Patrícia M PM Nunes Fabio D FD Nishimoto Ines Nobuko IN Soares Fernando A FA Soares Fernando A FA da Silva Adriana M A AM Kowalski Luis P LP Brentani Helena H Zanelli Cleslei F CF Silva Wilson A WA Rahal Paula P Tajara Eloiza H EH Carraro Dirce M DM Camargo Anamaria A AA Valentini Sandro R SR
Neoplasia (New York, N.Y.) 20091201 12
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease affecting the epithelium of the oral cavity, pharynx and larynx. Conditions of most patients are diagnosed at late stages of the disease, and no sensitive and specific predictors of aggressive behavior have been identified yet. Therefore, early detection and prognostic biomarkers are highly desirable for a more rational management of the disease. Hypermethylation of CpG islands is one of the most important epigenetic mechan ...[more]