Ontology highlight
ABSTRACT:
SUBMITTER: Jorgensen ND
PROVIDER: S-EPMC2794542 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
PloS one 20091224 12
<h4>Background</h4>Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson disease (PD). LRRK2 contains an "enzymatic core" composed of GTPase and kinase domains that is flanked by leucine-rich repeat (LRR) and WD40 protein-protein interaction domains. While kinase activity and GTP-binding have both been implicated in LRRK2 neurotoxicity, the potential role of other LRRK2 domains has not been as extensively explored.<h4>Principal findings</h4>We demonstra ...[more]