Ontology highlight
ABSTRACT:
SUBMITTER: Yao P
PROVIDER: S-EPMC2794838 | biostudies-literature | 2008 Oct-Dec
REPOSITORIES: biostudies-literature
Yao Peggy P Dhanik Ankur A Marz Nathan N Propper Ryan R Kou Charles C Liu Guanfeng G van den Bedem Henry H Latombe Jean-Claude JC Halperin-Landsberg Inbal I Altman Russ Biagio RB
IEEE/ACM transactions on computational biology and bioinformatics 20081001 4
Several applications in biology - e.g., incorporation of protein flexibility in ligand docking algorithms, interpretation of fuzzy X-ray crystallographic data, and homology modeling - require computing the internal parameters of a flexible fragment (usually, a loop) of a protein in order to connect its termini to the rest of the protein without causing any steric clash. One must often sample many such conformations in order to explore and adequately represent the conformational range of the stud ...[more]