Ontology highlight
ABSTRACT:
SUBMITTER: Tian L
PROVIDER: S-EPMC2794957 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Tian Lifeng L Zhou Jie J Casimiro Mathew C MC Liang Bing B Ojeifo John O JO Wang Min M Hyslop Terry T Wang Chenguang C Pestell Richard G RG
Cancer research 20091201 24
Peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in a variety of cancer cells. The addition of ligand activates the receptor by inducing a conformational change in the receptor, which can be recapitulated by mutation. To investigate the role of activated PPARgamma signaling in breast cancer, we compared the function of a constitutively active PPARgamma (PgammaCA) mutant with the wild-type PPARgamma in ErbB2-induced mammary tumorigenesis in vivo. Tumor cells transduced wi ...[more]