Ontology highlight
ABSTRACT:
SUBMITTER: Kotlyar AB
PROVIDER: S-EPMC2794998 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Kotlyar Alexander B AB Randazzo Antonio A Honbo Norman N Jin Zhu-Qui ZQ Karliner Joel S JS Cecchini Gary G
FEBS letters 20100101 1
Alkaline incubation of NADH results in the formation of a very potent inhibitor of lactate dehydrogenase. High resolution mass spectroscopy along with NMR characterization clearly showed that the inhibitor is derived from attachment of a glycolic acid moiety to the 4-position of the dihydronicotinamide ring of NADH. The very potent inhibitor is competitive with respect to NADH. The inhibitor added in submicromolar concentrations to cardiomyocytes protects them from damage caused by hypoxia/reoxy ...[more]