Gene networks and microRNAs implicated in aggressive prostate cancer.
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ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC2795036 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Gene networks and microRNAs implicated in aggressive prostate cancer.
Wang Liang L Tang Hui H Thayanithy Venugopal V Subramanian Subbaya S Oberg Ann L AL Cunningham Julie M JM Cerhan James R JR Steer Clifford J CJ Thibodeau Stephen N SN
Cancer research 20091201 24
Prostate cancer, a complex disease, can be relatively harmless or extremely aggressive. To identify candidate genes involved in causal pathways of aggressive prostate cancer, we implemented a systems biology approach by combining differential expression analysis and coexpression network analysis to evaluate transcriptional profiles using lymphoblastoid cell lines from 62 prostate cancer patients with aggressive phenotype (Gleason grade >or= 8) and 63 prostate cancer patients with nonaggressive p ...[more]
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