Ontology highlight
ABSTRACT:
SUBMITTER: Kantyka T
PROVIDER: S-EPMC2795110 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Kantyka Tomasz T Latendorf Ties T Wiedow Oliver O Bartels Joachim J Gläser Regine R Dubin Grzegorz G Schröder Jens-Michael JM Potempa Jan J Meyer-Hoffert Ulf U
Biological chemistry 20091201 12
Abstract Porphyromonas gingivalis, the major causative bacterium of periodontitis, contributes significantly to elevated proteolytic activity at periodontal pockets owing to the presence of both bacteria and host, predominantly neutrophil-derived, serine proteases. Normally the activity of the latter enzymes is tightly regulated by endogenous proteins, including elafin, a potent neutrophil elastase and proteinase 3 inhibitor released from epithelial cells at sites of inflammation. Here, we repor ...[more]