Ontology highlight
ABSTRACT:
SUBMITTER: Fox A
PROVIDER: S-EPMC2795391 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Fox A A Taylor D D Slonim D K DK
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20090101
Research in model organisms relies on unspoken assumptions about the conservation of protein-protein interactions across species, yet several analyses suggest such conservation is limited. Fortunately, for many purposes the crucial issue is not global conservation of interactions, but preferential conservation of functionally important ones. An observed bias towards essentiality in highly-connected proteins implies the functional importance of such "hubs". We therefore define the notion of degre ...[more]