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Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic.

ABSTRACT: Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.

SUBMITTER: Hendricks AE

PROVIDER: S-EPMC2795871 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic.

Hendricks Audrey E AE Zhu Yanyan Y Dupuis Josée J

BMC proceedings 20091215

Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly ...[more]

PMID: 20017964

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