Ontology highlight
ABSTRACT:
SUBMITTER: Mathew G
PROVIDER: S-EPMC2795881 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Mathew George G Xu Hongyan H George Varghese V
BMC proceedings 20091215
The availability of very large number of markers by modern technology makes genome-wide association studies very popular. The usual approach is to test single-nucleotide polymorphisms (SNPs) one at a time for association with disease status. However, it may not be possible to detect marginally significant effects by single-SNP analysis. Simultaneous analysis of SNPs enables detection of even those SNPs with small effect by evaluating the collective impact of several neighboring SNPs. Also, false ...[more]