Family-based genome-wide association study for simulated data of Framingham Heart Study.
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ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC2795897 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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Family-based genome-wide association study for simulated data of Framingham Heart Study.
Xu Hongyan H Mathew George G George Varghese V
BMC proceedings 20091215
Genome-wide association studies (GWAS) have quickly become the norm in dissecting the genetic basis of complex diseases. Family-based association approaches have the advantages of being robust to possible hidden population structure in samples. Most of these methods were developed with limited markers. Their applicability and performance for GWAS need to be examined. In this report, we evaluated the properties of the family-based association method implemented by ASSOC in the S.A.G.E package usi ...[more]
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