Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data.
Ontology highlight
ABSTRACT:
SUBMITTER: Ling H
PROVIDER: S-EPMC2795957 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Application of sex-specific single-nucleotide polymorphism filters in genome-wide association data.
Ling Hua H Hetrick Kurt K Bailey-Wilson Joan E JE Pugh Elizabeth W EW
BMC proceedings 20091215
We explored five sex-specific quality control filters in North American Rheumatoid Arthritis Consortium's Illumina 550 k datasets. Three X chromosome and three autosomal single-nucleotide polymorphisms flagged by sex quality control filters were missed by filters of call rate at 95% and Hardy-Weinberg equilibrium at 10-6. We applied a subset of these sex-specific quality control filters to eight chromosomes in the Framingham Heart Study samples genotyped by Affymetrix 500 k SNP arrays, and ident ...[more]
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