Ontology highlight
ABSTRACT:
SUBMITTER: Clarke GM
PROVIDER: S-EPMC2795975 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Clarke Geraldine M GM Pettersson Fredrik H FH Morris Andrew P AP
BMC proceedings 20091215
We compare and contrast case-only designs for detecting gene x gene (G x G) interaction in rheumatoid arthritis (RA) using the genome-wide data provided by Genetic Analysis Workshop 16 Problem 1. Logistic as well as novel multinomial and proportional odds models that do not depend on the specification of additive or dominant models for susceptibility loci were applied to the case-only sample. We identified 519 significant interactions (p < 1 x 10-4 in at least one test). All methods detected uni ...[more]