Ontology highlight
ABSTRACT:
SUBMITTER: Perona-Wright G
PROVIDER: S-EPMC2796259 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Cell host & microbe 20091201 6
Surviving infection represents a balance between the proinflammatory responses needed to eliminate the pathogen, and anti-inflammatory signals limiting damage to the host. IL-10 is a potent immunosuppressive cytokine whose impact is determined by the timing and localization of release. We show that NK cells rapidly express IL-10 during acute infection with diverse rapidly disseminating pathogens. The proinflammatory cytokine IL-12 was necessary and sufficient for NK cell induction of IL-10. NK c ...[more]