Ontology highlight
ABSTRACT:
SUBMITTER: Smith PD
PROVIDER: S-EPMC2796263 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Smith Patrice D PD Sun Fang F Park Kevin Kyungsuk KK Cai Bin B Wang Chen C Kuwako Kenichiro K Martinez-Carrasco Irene I Connolly Lauren L He Zhigang Z
Neuron 20091201 5
Axon regeneration failure accounts for permanent functional deficits following CNS injury in adult mammals. However, the underlying mechanisms remain elusive. In analyzing axon regeneration in different mutant mouse lines, we discovered that deletion of suppressor of cytokine signaling 3 (SOCS3) in adult retinal ganglion cells (RGCs) promotes robust regeneration of injured optic nerve axons. This regeneration-promoting effect is efficiently blocked in SOCS3-gp130 double-knockout mice, suggesting ...[more]