A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.
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ABSTRACT:
SUBMITTER: van Rooij E
PROVIDER: S-EPMC2796371 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.
van Rooij Eva E Quiat Daniel D Johnson Brett A BA Sutherland Lillian B LB Qi Xiaoxia X Richardson James A JA Kelm Robert J RJ Olson Eric N EN
Developmental cell 20091101 5
Myosin is the primary regulator of muscle strength and contractility. Here we show that three myosin genes, Myh6, Myh7, and Myh7b, encode related intronic microRNAs (miRNAs), which, in turn, control muscle myosin content, myofiber identity, and muscle performance. Within the adult heart, the Myh6 gene, encoding a fast myosin, coexpresses miR-208a, which regulates the expression of two slow myosins and their intronic miRNAs, Myh7/miR-208b and Myh7b/miR-499, respectively. miR-208b and miR-499 play ...[more]
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