Ontology highlight
ABSTRACT:
SUBMITTER: Williams AH
PROVIDER: S-EPMC2796560 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Williams Andrew H AH Valdez Gregorio G Moresi Viviana V Qi Xiaoxia X McAnally John J Elliott Jeffrey L JL Bassel-Duby Rhonda R Sanes Joshua R JR Olson Eric N EN
Science (New York, N.Y.) 20091201 5959
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of motor neurons, denervation of target muscles, muscle atrophy, and paralysis. Understanding ALS pathogenesis may require a fuller understanding of the bidirectional signaling between motor neurons and skeletal muscle fibers at neuromuscular synapses. Here, we show that a key regulator of this signaling is miR-206, a skeletal muscle-specific microRNA that is dramatically induced in a mouse model of ALS. Mic ...[more]