Computational analysis of membrane proteins: the largest class of drug targets.
Ontology highlight
ABSTRACT:
SUBMITTER: Arinaminpathy Y
PROVIDER: S-EPMC2796609 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Computational analysis of membrane proteins: the largest class of drug targets.
Arinaminpathy Yalini Y Khurana Ekta E Engelman Donald M DM Gerstein Mark B MB
Drug discovery today 20090903 23-24
Given the key roles of integral membrane proteins as transporters and channels, it is necessary to understand their structures and, hence, mechanisms and regulation at the molecular level. Membrane proteins represent approximately 30% of all proteins of currently sequenced genomes. Paradoxically, however, only approximately 2% of crystal structures deposited in the protein data bank are of membrane proteins, and very few of these are at high resolution (better than 2A). The great disparity betwe ...[more]
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