Ontology highlight
ABSTRACT:
SUBMITTER: Windish HP
PROVIDER: S-EPMC2796623 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Windish Hillarie Plessner HP Lin P Ling PL Mattila Joshua T JT Green Angela M AM Onuoha Ezenwa Obi EO Kane Lawrence P LP Flynn JoAnne L JL
Journal of leukocyte biology 20090519 3
Foxp3+ T regulatory cells are required to prevent autoimmune disease, but also prevent clearance of some chronic infections. While natural T regulatory cells are produced in the thymus, TGF-beta1 signaling combined with T-cell receptor signaling induces the expression of Foxp3 in CD4+ T cells in the periphery. We found that ICAM-1-/- mice have fewer T regulatory cells in the periphery than WT controls, due to a role for ICAM-1 in induction of Foxp3 expression in response to TGF-beta1. Further in ...[more]