Ontology highlight
ABSTRACT:
SUBMITTER: Minakhina S
PROVIDER: S-EPMC2796932 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Minakhina Svetlana S Steward Ruth R
Development (Cambridge, England) 20100101 1
The Drosophila lymph gland, the source of adult hemocytes, is established by mid-embryogenesis. During larval stages, a pool of pluripotent hemocyte precursors differentiate into hemocytes that are released into circulation upon metamorphosis or in response to immune challenge. This process is controlled by the posterior signaling center (PSC), which is reminiscent of the vertebrate hematopoietic stem cell niche. Using lineage analysis, we identified bona fide hematopoietic stem cells (HSCs) in ...[more]