Palmitoylation of hepatitis C virus core protein is important for virion production.
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ABSTRACT:
SUBMITTER: Majeau N
PROVIDER: S-EPMC2797162 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Palmitoylation of hepatitis C virus core protein is important for virion production.
Majeau Nathalie N Fromentin Rémi R Savard Christian C Duval Marie M Tremblay Michel J MJ Leclerc Denis D
The Journal of biological chemistry 20090916 49
Hepatitis C virus core protein is the viral nucleocapsid of hepatitis C virus. Interaction of core with cellular membranes like endoplasmic reticulum (ER) and lipid droplets (LD) appears to be involved in viral assembly. However, how these interactions with different cellular membranes are regulated is not well understood. In this study, we investigated how palmitoylation, a post-translational protein modification, can modulate the targeting of core to cellular membranes. We show that core is pa ...[more]
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