Ontology highlight
ABSTRACT:
SUBMITTER: Knowles MA
PROVIDER: S-EPMC2797439 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Knowles Margaret A MA Platt Fiona M FM Ross Rebecca L RL Hurst Carolyn D CD
Cancer metastasis reviews 20091201 3-4
The phosphatidylinositol 3-kinase (PI3K) pathway is a critical signal transduction pathway that regulates multiple cellular functions. Aberrant activation of this pathway has been identified in a wide range of cancers. Several pathway components including AKT, PI3K and mTOR represent potential therapeutic targets and many small molecule inhibitors are in development or early clinical trials. The complex regulation of the pathway, together with the multiple mechanisms by which it can be activated ...[more]