Structural and functional roles of coevolved sites in proteins.

ABSTRACT:

Background

Understanding the residue covariations between multiple positions in protein families is very crucial and can be helpful for designing protein engineering experiments. These simultaneous changes or residue coevolution allow protein to maintain its overall structural-functional integrity while enabling it to acquire specific functional modifications. Despite the significant efforts in the field there is still controversy in terms of the preferable locations of coevolved residues on different regions of protein molecules, the strength of coevolutionary signal and role of coevolution in functional diversification.

Methodology

In this paper we study the scale and nature of residue coevolution in maintaining the overall functionality and structural integrity of protein

SUBMITTER: Chakrabarti S 

PROVIDER: S-EPMC2797611 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature