Ontology highlight
ABSTRACT:
SUBMITTER: Belforte JE
PROVIDER: S-EPMC2797836 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Belforte Juan E JE Zsiros Veronika V Sklar Elyse R ER Jiang Zhihong Z Yu Gu G Li Yuqing Y Quinlan Elizabeth M EM Nakazawa Kazu K
Nature neuroscience 20091115 1
Cortical GABAergic dysfunction may underlie the pathophysiology of psychiatric disorders, including schizophrenia. Here, we characterized a mouse strain in which the essential NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development. Consistent with the NMDAR hypofunction theory of schizophrenia, distinct schizophrenia-related symptoms emerged after adolescence, including novelty-induced hyperlocomotion, ...[more]