Ontology highlight
ABSTRACT:
SUBMITTER: Karami S
PROVIDER: S-EPMC2798114 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Karami S S Brennan P P Navratilova M M Mates D D Zaridze D D Janout V V Kollarova H H Bencko V V Matveev V V Szesznia-Dabrowska N N Holcatova I I Yeager M M Chanock S S Rothman N N Boffetta P P Chow W-H WH Moore L E LE
International journal of endocrinology 20091105
Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whether VDR and RXRA polymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A ...[more]