Ontology highlight
ABSTRACT:
SUBMITTER: Kobiyama K
PROVIDER: S-EPMC2798368 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Kobiyama Kouji K Takeshita Fumihiko F Jounai Nao N Sakaue-Sawano Asako A Miyawaki Atsushi A Ishii Ken J KJ Kawai Taro T Sasaki Shin S Hirano Hisashi H Ishii Norihisa N Okuda Kenji K Suzuki Koichi K
Journal of virology 20091111 2
Fragments of double-stranded DNA (dsDNA) forming a right-handed helical structure (B-DNA) stimulate cells to produce type I interferons (IFNs). While an adaptor molecule, IFN-beta promoter stimulator 1 (IPS-1), mediates dsDNA-induced cellular signaling in human cells, the underlying molecular mechanism is not fully understood. Here, we demonstrate that the extrachromosomal histone H2B mediates innate antiviral immune responses in human cells. H2B physically interacts with IPS-1 through the assoc ...[more]