7-ketocholesterol catabolism by Rhodococcus jostii RHA1.
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ABSTRACT:
SUBMITTER: Mathieu JM
PROVIDER: S-EPMC2798662 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
7-ketocholesterol catabolism by Rhodococcus jostii RHA1.
Mathieu Jacques M JM Mohn William W WW Eltis Lindsay D LD LeBlanc Justin C JC Stewart Gord R GR Dresen Carola C Okamoto Kenji K Alvarez Pedro J J PJ
Applied and environmental microbiology 20091030 1
Oxysterols from steroid autooxidation have numerous harmful effects, but their biodegradation is poorly understood. Microarrays were used to study mineralization of the most common oxysterol, 7-ketocholesterol (7KC), by Rhodococcus jostii RHA1. Growth on 7KC versus growth on cholesterol resulted in 363 differentially expressed genes, including upregulation of two large gene clusters putatively encoding steroid catabolism. Despite this difference, 7KC degradation required key genes involved in ch ...[more]
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